The Pats jumped out to a 2-0 lead after the opening period after Sam Steel scored on the powerplay for his 11th and then Jake Leschyshyn added his sixth.
In the second, Red Deer got one back on a five on three powerplay and it was 2-1 Regina after 40 minutes.
In the third, Matt Bradley scored on the powerplay, his team leading 18th, to make it a 3-1 game. The Rebels drew to within a goal with just over two minutes left but Sam Steel sealed it with an empty netter, his second of the night and 4-2 was the final score.
The Pats outshot Red Deer 31-23, the powerplay was two for three and the penalty kill four for five.
Sam Steel and Nick Henry led the way with three points each while Tyler Brown made 21 saves in a first star performance.
The Pats (14-12-2) are back in action on Sunday in Calgary against the Hitmen. Puck drops at 5 p.m. Regina time on 620 CKRM. Next home game is Friday, December 8 against the Kelowna Rockets on Teddy Bear Toss Night at the Brandt Centre. Tickets are available at reginapats.com, the Brandt Centre Box office and at all Regina Safeway locations, Safeway Funzone tickets are just $13 plus tax.