Ty Lewis led the home side with two goals and three assists while Stelio Mattheos and Cole Reinhardt chipped in with two goals of their own.
Matt Bradley scored the lone goal for Regina late in the first on the powerplay.
The Wheat Kings led 3-1 and 5-1 by periods.
The Regina powerplay was one for five while the penalty kill went two for five.
Tyler Brown and Max Paddock combined to make 37 saves in the Regina goal as the Wheat Kings outshot Regina 45-34.
The Pats will host Brandon for their home opener at the Brandt Centre on Saturday night at 7 p.m. Tickets are available at reginapats.com and the Brandt Centre Box Office.