The Pats opened the scoring on the powerplay thanks to Nick Henry in the first period. Ty Lewis tied the game for Brandon later in the frame.
The goaltenders took over from there and the game went to a shootout after 60 minutes, tied 1-1.
Tyler Coulter scored the lone goal on penalty shots and the Wheat Kings took the extra point. Sam Steel, Nick Henry and Adam Brooks were all stymied for the Pats.
Tyler Brown earned second star honours, making 34 saves in the loss. Logan Thompson of the Wheat Kings was the first star with 39 saves in the Brandon goal.
Regina outshot Brandon 40-35 while going 1/7 on the powerplay and 4/4 killing penalties.
The attendance was 4339.
The loss dropped the Pats' record to 23-3-6-1 on the season.
- The Pats penalty kill has scored twice and not allowed a goal in their last 17 shorthanded situations.
- Adam Brooks has tied teammate Sam Steel for the WHL scoring lead with 59 points.
- Tyler Brown made 34 saves in his 13th straight start in the Pats goal.
The return to action Friday night when they visit the Prince Albert Raiders. Puck drop from the Art Hauser Centre is at 7 p.m. on 620 CKRM. Next home game is Sunday in a rematch with P.A. at the Brandt Centre at 4 p.m. Tickets are available at reginapats.com or at the Brandt Centre Box Office.
(With files from Phil Andrews/ReginaPats.com)