The Stampeders haven't lost a game since their season-opener.
Andrew Buckley and Jerome Messam scored rushing touchdowns for the hosts.
Bo Levi Mitchell threw to Marquay McDaniel and DeVaris Daniels for touchdowns. Jamar Wall returned an interception to score and Ja'Gared Davis off a fumble recovery for a pair of defensive touchdowns.
Rene Paredes added a pair of field goals for the Stampeders.
Ottawa quarterback Trevor Harris threw touchdown passes to Ernest Jackson and Greg Ellingson. Chris Milo kicked three field goals in a losing cause.