Drew Willy, Winnipeg's starting quarterback, left the field with a suspected head injury.
Willy was injured with 20 seconds remaining in the first quarter when he took a helmet-to-helmet hit from Ticats defensive end Adrian Tracy.
Willy appeared to be knocked out as medical staff looked at him. After a couple minutes on the turf, he walked off the field to the locker-room and was replaced by Brian Brohm.
He's the fifth quarterback to be injured in the first two weeks of the CFL season, joining Montreal's Jonathan Crompton and Dan LeFevour, Edmonton's Mike Reilly and Saskatchewan veteran Darian Durant on the sidelines.
Hamilton (1-1) had a 17-7 lead after the first quarter and 38-7 at halftime. The team announced on Twitter that the 38 points was the most first-half points for a road team in 23 years.
Collaros completed 26-of-33 pass attempts, including a 35-yard toss to Bakari Grant and a three-yard pass to Terrence Toliver.
Hamilton kicker Justin Medlock was good on field goals from 19, 32 and 38 yards and made all his converts.
Willy was 3-of-6 for 48 yards. Brohm finished 16-of-28 for 146 yards and two interceptions. He scored a touchdown on a 16-yard run in front of 27,279 fans at the Bombers home opener at Investors Group Field.
Winnipeg (1-1) scored points off a 13-yard run by Paris Cotton and a four-yarder by Cameron Marshall.